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Table 1 TAED gene family lineages with the largest dN/dS values where dS > 0.001

From: Characterizing lineage-specific evolution and the processes driving genomic diversification in chordates

TAED Gene Families with high dN/dS
FamilydN/dS ValueMapped Location on Chordate Species Tree (Start to End)Family descriptionKEGG Pathways
151,76688.7785Boreoeutheria to Laurasiatheriasplicing factor arginine/serine-rich 4/5/6Herpes simplex infection; Spliceosome
3076.4909Cercopithecidae to Cercopithecidaetransmembrane protein 91 isoform X1 
60,78763.0029Euarchontoglires to Simiiformesfucose-1-phosphate guanylyltransferaseMetabolic pathways; Fructose and mannose metabolism; Amino sugar and nucleotide sugar metabolism
23,13361.9262Aves to Avesgalanin receptor 1Neuroactive ligand-receptor interaction
296,34655.184Eutheria to DelphinidaeLOW QUALITY PROTEIN: probable N-acetyltransferase 16 
21,90045.0176Boreoeutheria to BoreoeutheriaX-linked interleukin-1 receptor accessory protein-like 2 
52,18144.575Boreoeutheria to Laurasiatheriaunnamed protein product 
818644.3077Sauria to Anolis carolinensisprotein Simiate 
937840.3796Neognathae to Neognathaepalmitoyltransferase ZDHHC17 isoform X4 
22,60039.9557Boreoeutheria to Laurasiatheriapotassium voltage-gated channel subfamily G member 3 isoform X1 
414438.9415Hystricognathi to Hystricognathipygopus homolog 1 
14,87538.1267Laurasiatheria to Laurasiatheriakinesin-like protein KIF16B 
12,21338.0258Camelidae to CamelusLOW QUALITY PROTEIN: dnaJ homolog subfamily B member 3 
12,59337.1258Boreoeutheria to BoreoeutheriatRNA (guanine(10)-N2)-methyltransferase homolog 
20,70836.782Amniota to Amniotaheparan sulfate 2-O-sulfotransferase HS2ST1Glycosaminoglycan biosynthesis - heparan sulfate / heparin
32,53236.0215Boreoeutheria to Carlito syrichtainterleukin 8AGE-RAGE signaling pathway in diabetic complications; NOD-like receptor signaling pathway;Influenza A; Phospholipase D signaling pathway; Chemokine signaling pathway;Hepatitis B; Toll-like receptor signaling pathway; Legionellosis;RIG-I-like receptor signaling pathway; Rheumatoid arthritis; Malaria; NF-kappa B signaling pathway; Shigellosis;Hepatitis C;N on-alcoholic fatty liver disease (NAFLD); Pathways in cancer; Epithelial cell signaling in Helicobacter pylori infection; Amoebiasis; Bladder cancer; IL-17 signaling pathway; Chagas disease (American trypanosomiasis); Pertussis; Transcriptional misregulation in cancer; Salmonella infection; Cytokine-cytokine receptor interaction
427335.4369Laurasiatheria to Laurasiatheriamyelin protein zeroCell adhesion molecules (CAMs)
21,94435.0114Boreoeutheria to Boreoeutheriaadrenergic receptor alpha-2CcGMP-PKG signaling pathway; Neuroactive ligand-receptor interaction
14,30334.6434Neognathae to NeognathaeATP-dependent DNA helicase PIF1 partial 
14,58834.0198Neognathae to Neognathaeorganic solute transporter subunit alpha-like partial 
12,29934.0037Neognathae to Neognathaephosphatidylinositol glycan class HGlycosylphosphatidylinositol (GPI)-anchor biosynthesis; Metabolic pathways
876233.6089Myotis to Myotisdoublesex- and mab-3-related transcription factor 2 isoform X1 
55,19631.2663Murinae to Mus musculusIsx protein 
14,11931.0551Passeriformes to Passeriformescardiolipin synthase CMP-formingGlycerophospholipid metabolism; Metabolic pathways
3930.43Boreoeutheria to Boreoeutherialarge subunit ribosomal protein L4eRibosome
23,59630.0168Neognathae to Neognathaediacylglycerol cholinephosphotransferasePhosphonate and phosphinate metabolism; Glycerophospholipid metabolism; Metabolic pathways; Choline metabolism in cancer; Ether lipid metabolism
10,50129.8433Homo sapiens to Homo sapienssmoothelin isoform X5 
157,10327.6427Neognathae to Haliaeetus albicillanucleolar protein 7 partial 
371727.4352Boreoeutheria to Boreoeutheriaglypican 4Wnt signaling pathway
972526.5684Eutheria to Boreoeutheriacilia- and flagella-associated protein 221-like partial