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Table 2 Pathways present in lineages under positive selection

From: Characterizing lineage-specific evolution and the processes driving genomic diversification in chordates

Over-Represented KEGG Pathways TAED
KEGG PathwayMapped Lineages Under Positive SelectionLineages Under Positive Selection MappedUncorrected P-valueFDR P-valueBonferroni P-value
Metabolic pathways7.63%5.73%<  0.0001<  0.0001<  0.0001
Olfactory transduction12.25%2.67%<  0.0001<  0.0001<  0.0001
Biosynthesis of secondary metabolites7.85%1.90%<  0.0001<  0.0001<  0.0001
Biosynthesis of antibiotics7.96%1.11%<  0.0001<  0.0001<  0.0001
Neuroactive ligand-receptor interaction6.45%1.05%<  0.0001<  0.0001<  0.0001
Microbial metabolism in diverse environments7.86%0.85%<  0.0001<  0.0001<  0.0001
Protein processing in endoplasmic reticulum6.97%0.72%<  0.0001<  0.0001<  0.0001
Purine metabolism6.63%0.69%<  0.0001<  0.0001<  0.0001
Herpes simplex infection6.18%0.68%0.00470.01281.0000
Carbon metabolism8.63%0.62%<  0.0001<  0.0001<  0.0001
RNA transport6.45%0.59%<  0.0001<  0.00010.0056
Influenza A6.74%0.59%<  0.0001<  0.0001<  0.0001
Fluid shear stress and atherosclerosis6.21%0.54%0.00610.0161.0000
Lysosome6.72%0.52%<  0.0001<  0.0001<  0.0001
Glycerophospholipid metabolism7.61%0.49%<  0.0001<  0.0001<  0.0001
Non-alcoholic fatty liver disease (NAFLD)6.19%0.47%0.01280.03251.0000
Pancreatic secretion8.86%0.43%<  0.0001<  0.0001<  0.0001
Peroxisome7.37%0.42%<  0.0001<  0.0001<  0.0001
Toxoplasmosis6.50%0.41%0.00010.00030.0341
Phosphatidylinositol signaling system6.70%0.41%<  0.0001<  0.00010.0004
Glycerolipid metabolism10.21%0.39%<  0.0001<  0.0001<  0.0001
Drug metabolism - cytochrome P45012.03%0.39%<  0.0001<  0.0001<  0.0001
Th17 cell differentiation6.38%0.38%0.00130.00390.4944
Valine_ leucine and isoleucine degradation11.00%0.38%<  0.0001<  0.0001<  0.0001
Chemical carcinogenesis9.32%0.38%<  0.001<  0.0001<  0.0001
  1. The top 25 over-represented KEGG pathways with the highest % of lineages under positive selection mapping to a pathway. All pathways were significant at the 0.05 level after correction with the false discovery rate (FDR). Bold numbers indicate not significant at the 0.05 level. Lineages with dN/dS > 1 considered under positive selection