Over-Represented CATH Domain Topologies in TAED | |||||
---|---|---|---|---|---|
CATH domain topology | Mapped Lineages Under Positive Selection | Lineages Under Positive Selection Mapped | Uncorrected P-value | FDR P-value | Bonferroni P-value |
Rossmann fold | 7.35% | 25.55% | <  0.0001 | <  0.0001 | <  0.0001 |
Jelly Rolls | 7.30% | 4.43% | <  0.0001 | <  0.0001 | 0.0013 |
Phosphorylase Kinase domain 1 | 9.51% | 3.87% | <  0.0001 | <  0.0001 | <  0.0001 |
TIM Barrel | 7.52% | 3.59% | <  0.0001 | <  0.0001 | <  0.0001 |
Thrombin subunit H | 11.13% | 2.90% | <  0.0001 | <  0.0001 | <  0.0001 |
Ubiquitin-like (UB roll) | 7.06% | 2.50% | 0.0143 | 0.0355 | 1.0000 |
Glutaredoxin | 9.53% | 2.39% | <  0.0001 | <  0.0001 | <  0.0001 |
Collagenase (Catalytic Domain) | 9.70% | 2.22% | <  0.0001 | <  0.0001 | <  0.0001 |
DNA polymerase domain 1 | 8.26% | 2.12% | <  0.0001 | <  0.0001 | <  0.0001 |
OB fold (Dihydrolipoamide Acetyltransferase E2P) | 7.32% | 1.79% | 0.0013 | 0.0039 | 0.8113 |
Methane Monooxygenase Hydroxylase Chain G domain 1 | 8.24% | 1.55% | <  0.0001 | <  0.0001 | <  0.0001 |
Cytochrome p450 | 9.11% | 1.51% | <  0.0001 | <  0.0001 | <  0.0001 |
Helicase Ruva Protein domain 3 | 9.86% | 1.21% | <  0.0001 | <  0.0001 | <  0.0001 |
Laminin | 8.56% | 1.03% | <  0.0001 | <  0.0001 | <  0.0001 |
Glutathione S-transferase Yfyf (Class Pi) Chain A domain 2 | 10.79% | 1.01% | <  0.0001 | <  0.0001 | <  0.0001 |
Kinesin | 8.47% | 1.00% | <  0.0001 | <  0.0001 | <  0.0001 |
Glycosyltransferase | 12.75% | 0.92% | <  0.0001 | <  0.0001 | <  0.0001 |
FAD/NAD(P)-binding domain | 10.68% | 0.87% | <  0.0001 | <  0.0001 | <  0.0001 |
2-enoyl-CoA Hydratase Chain A domain 1 | 14.07% | 0.80% | <  0.0001 | <  0.0001 | <  0.0001 |
Erythroid Transcription Factor GATA-1 Chain A | 9.34% | 0.72% | <  0.0001 | <  0.0001 | <  0.0001 |
Cyclin A domain 1 | 10.32% | 0.71% | <  0.0001 | <  0.0001 | <  0.0001 |
Alkaline Phosphatase subunit A | 9.96% | 0.69% | <  0.0001 | <  0.0001 | <  0.0001 |
Butyryl-CoA Dehydrogenase subunit A domain 3 | 9.13% | 0.68% | <  0.0001 | <  0.0001 | <  0.0001 |
Carbonic Anhydrase II | 14.52% | 0.66% | <  0.0001 | <  0.0001 | <  0.0001 |