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Table 4 Domains present in lineages under positive selection

From: Characterizing lineage-specific evolution and the processes driving genomic diversification in chordates

Over-Represented CATH Domain Topologies in TAED
CATH domain topologyMapped Lineages Under Positive SelectionLineages Under Positive Selection MappedUncorrected P-valueFDR P-valueBonferroni P-value
Rossmann fold7.35%25.55%<  0.0001<  0.0001<  0.0001
Jelly Rolls7.30%4.43%<  0.0001<  0.00010.0013
Phosphorylase Kinase domain 19.51%3.87%<  0.0001<  0.0001<  0.0001
TIM Barrel7.52%3.59%<  0.0001<  0.0001<  0.0001
Thrombin subunit H11.13%2.90%<  0.0001<  0.0001<  0.0001
Ubiquitin-like (UB roll)7.06%2.50%0.01430.03551.0000
Glutaredoxin9.53%2.39%<  0.0001<  0.0001<  0.0001
Collagenase (Catalytic Domain)9.70%2.22%<  0.0001<  0.0001<  0.0001
DNA polymerase domain 18.26%2.12%<  0.0001<  0.0001<  0.0001
OB fold (Dihydrolipoamide Acetyltransferase E2P)7.32%1.79%0.00130.00390.8113
Methane Monooxygenase Hydroxylase Chain G domain 18.24%1.55%<  0.0001<  0.0001<  0.0001
Cytochrome p4509.11%1.51%<  0.0001<  0.0001<  0.0001
Helicase Ruva Protein domain 39.86%1.21%<  0.0001<  0.0001<  0.0001
Laminin8.56%1.03%<  0.0001<  0.0001<  0.0001
Glutathione S-transferase Yfyf (Class Pi) Chain A domain 210.79%1.01%<  0.0001<  0.0001<  0.0001
Kinesin8.47%1.00%<  0.0001<  0.0001<  0.0001
Glycosyltransferase12.75%0.92%<  0.0001<  0.0001<  0.0001
FAD/NAD(P)-binding domain10.68%0.87%<  0.0001<  0.0001<  0.0001
2-enoyl-CoA Hydratase Chain A domain 114.07%0.80%<  0.0001<  0.0001<  0.0001
Erythroid Transcription Factor GATA-1 Chain A9.34%0.72%<  0.0001<  0.0001<  0.0001
Cyclin A domain 110.32%0.71%<  0.0001<  0.0001<  0.0001
Alkaline Phosphatase subunit A9.96%0.69%<  0.0001<  0.0001<  0.0001
Butyryl-CoA Dehydrogenase subunit A domain 39.13%0.68%<  0.0001<  0.0001<  0.0001
Carbonic Anhydrase II14.52%0.66%<  0.0001<  0.0001<  0.0001
  1. Enrichment analysis of CATH domain topologies in TAED showing CATH domains topologies present in highest % of lineages under positive selection. All pathways were significant at the 0.05 level after correction with the false discovery rate (FDR). Bold numbers indicate not significant at the 0.05 level. Lineages with dN/dS > 1 considered under positive selection