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Table 8 Sitewise substitution rates in TAED lineages sorted by selective pressure and structural features

From: Characterizing lineage-specific evolution and the processes driving genomic diversification in chordates

 Positively Selected Lineages (dN/dS > 1)Negatively Selected Lineages (dN/dS < 0.5)
Substituted SitespAll SitesSubstituted SitespAll Sites
Helix30.2826%< 0.000134.0597%35.2377%< 0.000136.6327%
Exposed17.1142%0.000216.4580%20.2511%< 0.000117.3397%
Buried13.1684%< 0.000117.6017%14.9866%< 0.000119.2929%
α-Helix26.1346%< 0.000130.1108%31.1229%< 0.000132.7617%
Exposed14.3764%0.165914.1740%17.5250%< 0.000115.1730%
Buried11.7582%< 0.000115.9368%13.5979%< 0.000117.5887%
310 Helix3.4956%0.00983.3039%3.5115%< 0.00013.2213%
Exposed2.3597%< 0.00012.0045%2.4163%< 0.00011.8907%
Buried1.1359%0.00041.2994%1.0952%< 0.00011.3306%
π-Helix0.6524%0.80470.6449%0.6033%< 0.00010.6497%
Exposed0.3780%< 0.00010.2794%0.3098%< 0.00010.2761%
Buried0.2743%0.00050.3655%0.2935%< 0.00010.3736%
β-Sheet23.2104%< 0.000121.7820%18.2981%< 0.000119.8385%
Exposed8.9360%< 0.00017.1998%7.3255%< 0.00016.2661%
Buried14.2744%0.036114.5822%10.9726%< 0.000113.5724%
β-Bridge1.1095%0.79131.0984%0.9888%< 0.00011.0382%
Exposed0.5644%0.00040.4641%0.4876%< 0.00010.4194%
Buried0.5451%0.00810.6343%0.5012%< 0.00010.6188%
Turn12.0729%< 0.000111.0540%12.3561%< 0.000111.0859%
Exposed9.7554%< 0.00018.3283%9.9588%< 0.00018.1517%
Buried2.3175%< 0.00012.7257%2.3973%< 0.00012.9342%
Bend10.4763%< 0.00019.7416%10.2628%< 0.00019.6989%
Exposed7.9179%< 0.00016.8552%7.8004%< 0.00016.6547%
Buried2.5584%< 0.00012.8864%2.4624%< 0.00013.0443%
Coil22.8482%0.000622.2643%22.8565%< 0.000121.7058%
Exposed15.2151%< 0.000113.2976%15.3522%< 0.000112.7858%
Buried7.6331%< 0.00018.9667%7.5044%< 0.00018.9201%
Buried (All Sites)40.4969%< 0.000147.3970%38.8245%< 0.000148.3826%
Exposed (All Sites)59.5031%< 0.000152.6030%61.1755%< 0.000151.6174%
  1. The distribution of substituted sites by secondary structure and solvent accessibility binned by the nautre of selection are shown. Bolded items are significant (p < 0.00167 after multiple comparisons correction) based on parametric bootstrapping, n = 20000