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Table 2 Polymorphisms in coding and non-coding regions of enterovirus (EV) 71 derived from viruses collected in different years.

From: Inferring nonneutral evolution from contrasting patterns of polymorphisms and divergences in different protein coding regions of enterovirus 71 circulating in Taiwan during 1998-2003

  

VP1

2A

3C

5'UTR

Genotype

Year

θs

θ

EV71-C2

1998

8.11%

(86, 35)

9.74%

(50, 19)

9.70%

(61, 24)

1.52%

(41, 7)

EV71-B4

2000

10.03%

(94, 49)

10.69%

(49, 28)

9.55%

(53, 18)

1.54%

(39, 12)

EV71-B4

2001

9.25%

(101, 54)

12.33%

(67, 28)

11.38%

(76, 46)

2.46%

(66, 11)

EV71-B4

2002

8.74%

(83, 47)

8.37%

(39, 28)

9.34%

(53, 35)

1.84%

(49, 23)

Average

8.87%

10.28%

9.99%

1.84%

p value (vs. VP1)

 

NS

NS

 

p value (vs. UTR)

0.014

0.014

0.014

 

p value (vs. UTR)A

0.021

0.041

0.041

 
  

θa

 

EV71-C2

1998

0.19%

(7, 2)

0.65%

(12, 2)

0.57%

(13, 6)

 

EV71-B4

2000

0.40%

(13, 7)

0.66%

(11, 4)

0.80%

(16, 6)

 

EV71-B4

2001

0.29%

(11, 5)

0.97%

(19, 5)

0.46%

(11, 8)

 

EV71-B4

2002

0.21%

(7, 3)

0.54%

(9, 1)

0.49%

(10, 4)

 

Average

0.25%

0.70%

0.58%

 

p value (vs. VP1)

 

0.014

0.014

 
  

θa/θs (N/S)B

 

EV71-C2

1998

2.35%

(0.08, 0.06)

6.69%

(0.24, 0.11)

5.87%

(0.21, 0.25)

 

EV71-B4

2000

3.99%

(0.14, 0.14)

6.19%

(0.22, 0.14)

8.35%

(0.30, 0.33)

 

EV71-B4

2001

3.11%

(0.11, 0.09)

7.87%

(0.28, 0.18)

4.06%

(0.14, 0.17)

 

EV71-B4

2002

2.43%

(0.08, 0.06)

6.41%

(0.23, 0.04)

5.25%

(0.19, 0.11)

 

Average

2.82%

(0.10, 0.09)

6.79%

(0.24, 0.12)

5.81%

(0.21, 0.22)

 

P-value(versus VP1)

 

0.014

(0.001, NS)

0.014

(0.014, 0.021)

 
  1. Numbers in parentheses are total number of mutations and number of mutations without singletons, respectively.
  2. p values are from the Mann-Whitney one-tailed test.
  3. NS, not significant (p > 0.05).
  4. A, Comparison of proportions of non-singleton mutations between different genomic regions.
  5. B, Ratios of nonsynonymous (N) to synonymous (S) mutations.