Figure 1

Multiple sequence alignment of the Xenopus and chicken 1-34 PTH family members mature peptide N-terminal region with teleost ( Takifugu and zebrafish) and mammals (human and mouse). Conserved amino acid positions identified in all vertebrates are indicated by "*" and percentage of sequence similarity in comparison with human PTH and PTHrP and Takifugu PTH-L is given. The typical three amino acid motifs characteristic of each PTH family member in positions 8 to 10 are indicated in black. % similarity to first sequence is indicated on the right. Accession number of the sequences used were: Human (PTH, AAH96144.1; PTHrP, AAA60216); Mouse (PTH, NP_065648; PTHrP, CAC39218.1); Zebrafish (PTHA, NP_998115.1; PTHB, NP_998114.1; PTHrPA, AAY87956.1; PTHrPB, AAY87957.1; PTH-L, CU856139); Takifugu (PTHA, CAG26460.1; PTHB, CAG26461.1; PTHrPA, CAB94712.1; PTHrPB, CAG26459.2; PTH-L, CAG26462.1).