From: Histone variant innovation in a rapidly evolving chordate lineage
 | M. musculus/H. Sapiens | O. dioica | C. intestinalis | C. savignyi | S. purpuratus | D. melanogaster | C. elegans | S. cerevisiae |
---|---|---|---|---|---|---|---|---|
Genomic organization | Large non-tandem clusters | Small, dispersed gene groups | Few dispersed genes | Large, mostly non-tandem clusters | Large tandem array clusters | Large tandem array clusters | Small, dispersed gene groups | Few dispersed genes |
H4 variants | Â | Â | Â | Â | Â | Â | Â | Â |
H4.1 | H4.1 | H4.1 | H4.1 | H4.1 | H4.1 | H4.1 | H4.1 | H4.1 |
H4t (testis) | - | H4t | - | nd | - | - | - | - |
+ isoforms§ | - | - | - | yes | - | - | - | - |
H3 variants | Â | Â | Â | Â | Â | Â | Â | Â |
H3.1 | H3.1 | - | - | - | - | - | - | - |
H3.2 | H3.2 | H3.2 | H3.2 | H3.2 | H3.2 | H3.2 | H3.2 | - |
H3.3 | H3.3 | H3.3 | H3.3 | H3.3 | H3.3 | H3.3 | H3.3 | H3.3 |
CenH3 | CENP-A | CenH3 | CenH3 | CenH3 | H3-Cid | CID | HCP-3 | CSE4 |
H3t (testis) | H3t | H3t.1 H3t.2 H3t.3 | - | nd | nd | Â | nd | - |
+ isoforms§ | yes | - | - | yes | yes | - | yes | - |
H2B variants | Â | Â | Â | Â | Â | Â | Â | Â |
H2B.1 | H2B.1 | H2B.1, H2B.2, H2B.3*1 | H2B.1 | H2B.1 | H2B.1 | H2B.1 | H2B.1 | Htb1p, Htb2p |
H2Bt (testis) | TSH2B H2BFWT spH2B | H2B.4*2 H2Bt.1 H2Bt.2 H2Bt.3 | nd | nd | SpermH2B | - | nd | - |
+ isoforms§ | yes | - | yes | yes | yes | - | yes | - |
H2A variants | Â | Â | Â | Â | Â | Â | Â | Â |
H2A.1 | H2A.1 | H2A.1, H2A.2 | H2A.1 | H2A.1 | H2A.1 | H2A.1 | H2A.1 | - |
H2A.Z | H2A.Z.1 H2A.Z.2 | H2A.Z | H2A.Z | H2A.Z | H2A.Z | H2Av | HTZ-1 | Htz1p |
H2AX | H2AX | - | H2AX | H2AX | H2AX | H2Av | - | Hta2p |
MacroH2A.1 | MacroH2A.1 | - | - | - | MacroH2A.1 | - | - | - |
MacroH2A.2 | MacroH2A.2 | - | - | - | MacroH2A.2 | - | - | - |
H2At (testis) | H2AL1 H2AL2 | H2At.1 H2At.2 H2At.3 H2Asq.1 H2Asq.2 H2Asq.3 | nd | nd | - | nd | nd | - |
H2A.Bbd | H2A.Bbd | - | - | - | - | - | - | - |
+ isoforms§ | yes | H2A.3*1 H2A.4*3 | yes | yes | yes | yes | yes | - |
H1 variants | Â | Â | Â | Â | Â | Â | Â | Â |
H1.1 | H1.1 H1.2 H1.3 H1.4 H1.5 | H1.1 H1.2*4 H1.3*5 H1.4*5 | 3 isoforms | 11 isoforms | H1 H1a H1b | H1 | 8 isoforms | Hho1p |
H1t (testis) | H1t H1T2 H1LS1 | H1t | Â | Â | SpermH1 | Â | Â | Â |
H1.oo (oocyte) | H1oo | Â | Â | Â | Â | Â | Â | Â |
H1.0 (diff)†| H1.0 H1.x |  |  |  | H1.0 |  |  |  |