The phylogenomic analysis of the anaphase promoting complex and its targets points to complex and modern-like control of the cell cycle in the last common ancestor of eukaryotes

Table 1 Taxonomic distribution of homologues of APC/C subunits and adaptors/co-activators in major lineages of eukaryotes.

	Catalytic arm			Structural complex			TPR arm subunits and associated proteins										Mitotic adaptors		Meiotic adaptors
	Apc10	Apc11	Apc2	Apc1	Apc4	Apc5	Apc8	Apc6	Apc3	Apc7	Apc12	Apc13	Apc16	Apc9	Apc15	Apc14	Cdc20	Cdh1	Ama1	Rap	Cortex
Holozoa/ Choanoflagellata	100		100	100	≥50		100	100	100	≥50							100	100
Holozoa/ Metazoa	100	100	100	100	100	100	100	100	100	100	≥50	≥50	< 50				100	100		< 50	< 50
Holozoa/ Capsaspora	100	100	100	100	100	100	100		100	100							100	100
Fungi/ Dikarya	100	100	100	100	100	100	100	100	100		≥50	≥50		< 50	< 50	< 50	100	100	≥50
Fungi/ Microsporidia	100	< 50		100			≥50	100	100								100	100
Fungi/ Chytridiomycota	≥50	100	100	100	≥50	≥50	100	100	100	100							100	100
Apusozoa	100	100	100	100	100	100	100	100	100								100	100
Amoebozoa	100	100	≥50	100	≥50	≥50	≥50	≥50	≥50	≥50	≥50	≥50					≥50	100
Excavata	≥50	≥50	≥50	≥50			≥50	≥50	≥50	< 50							≥50	< 50
Alveolata/ Ciliata	100	100	100	100	100		100	100	100								≥50	100
Alveolata/ Apicomplexa	≥50	≥50		< 50			< 50	< 50	< 50	≥50								≥50
Heterokonta	100	≥50	≥50	50	< 50	≥50	100	≥50	≥50	≥50	≥50	≥50					100	≥50
Plantae/ Viridiplantae	100	100	100	100	100	≥50	100	100	100	≥50	< 50	≥50					100	≥50
Plantae/ Rhodophyta	100	100	100	100			100	100	100								100	100
Haptophyta	100	100	100	100	100		100	100	100								100	100

100, > 50, and < 50 indicate that at least one orthologue has been detected respectively in all, at least 50%, and less than 50% of the studied genomes for a given lineage.

ISSN: 2730-7182