The relationship between the hierarchical position of proteins in the human signal transduction network and their rate of evolution

Table 1 Paired tests comparing upstream genes with their downstream targets

Parameter	n ^a	Upstream > Downstream^b	Upstream < Downstream^c	P
ω	800	446	352	0.001***
d _N	800	450	348	3.50×10^–4***
d _S	800	429	370	0.040*
Expression level	763	357	406	0.082
Expression breadth	763	261	337	0.002**
ENC	800	398	402	0.916
Connectivity	709	230	456	8.66×10^–18***
Number of paralogs	800	369	373	0.912

*, P<0.05; **, P<0.01, ***, P<0.001.
^aNumber of genes with at least one direct downstream target (out-degree>0). Only genes with available information for the parameter of interest were considered.
^bNumber of genes with a higher value than the central value of its downstream targets.
^cNumber of genes with a lower value than the central value of its downstream targets.

ISSN: 2730-7182