The relationship between the hierarchical position of proteins in the human signal transduction network and their rate of evolution

Table 3 Bivariate correlations between parameters of interest and measures of hierarchical positions of genes in the network

Variable 1	Variable 2	n	ρ	P
ω	in-degree	1049	−0.116	1.74×10^–4***
	out-degree	1049	−0.070	0.023*
	H	1049	0.067	0.031*
d _N	in-degree	1049	−0.117	1.44×10^–4***
	out-degree	1049	−0.072	0.019*
	H	1049	0.067	0.030*
d _S	in-degree	1049	−0.035	0.259
	out-degree	1049	−0.014	0.653
	H	1049	0.016	0.596
Expression level	in-degree	1016	0.019	0.553
	out-degree	1016	−0.035	0.258
	H	1016	−0.033	0.293
Expression breadth	in-degree	1016	0.054	0.084
	out-degree	1016	0.044	0.164
	H	1016	−0.039	0.218
ENC	in-degree	1049	0.012	0.705
	out-degree	1049	−0.022	0.480
	H	1049	−0.024	0.437
Connectivity	in-degree	951	0.275	5.07×10^–18***
	out-degree	951	0.230	7.38×10^–13***
	H	951	−0.016	0.621
Number of paralogs	in-degree	1049	0.023	0.466
	out-degree	1049	0.047	0.131
	H	1049	0.023	0.451

ISSN: 2730-7182