Figure 4
From: Covariance of maximum likelihood evolutionary distances between sequences aligned pairwise
Bias and standard deviation of the covariance and ML variance estimators. Average percentage of anchors vs. bias and standard deviation of the covariance estimator for sequence length of 500 AA. Error-bars indicate the 95% confidence intervals. The bias increases with decreasing fraction of anchors. The bias is smaller than the standard deviation when percentage of anchors is greater than 65% (dependence), 80% (triplet) and 75% (ML variance).