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Figure 4 | BMC Evolutionary Biology

Figure 4

From: Evolutionary history of the alpha2,8-sialyltransferase (ST8Sia) gene family: Tandem duplications in early deuterostomes explain most of the diversity found in the vertebrate ST8Sia genes

Figure 4

ClustalRO alignment of all the ST8Sia IV and ST8Sia II sequences ordered by the percentage of conserved amino acid positions specific to ST8Sia IV (yellow background) and ST8Sia II (orange background) present in each sequence. Five B. floridae ST8Sia II/IV sequences cannot be assigned to either ST8Sia II or ST8Sia IV subfamilies, because they contain the same proportion of ST8Sia II and ST8Sia IV specific amino acid positions (50 ± 9%). This intermediate position, with a relative large number of total ST8Sia II plus ST8Sia IV positions (28–31 out of 39 colored positions) suggests that these sequences are orthologues to the common ancestor, expected to be present before the duplication event responsible of the ST8Sia II and ST8Sia IV genes. The total number of subfamily-specific conserved amino acid positions is followed by the relative proportion (%) of ST8Sia II and ST8Sia IV specific positions for each protein. The first amino acid position of each line corresponds to the initial amino acid of sialylmotif L.

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BMC Ecology and Evolution

ISSN: 2730-7182

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