fabp1a | ||||||||||
WY14643 | Rosiglitazone | |||||||||
- | GW6471 | T0070907 | Δ5’FR | ΔDR1 | - | GW6471 | T0070907 | Δ5’FR | ΔDR1 | |
E max (RLU) | 152.80 ± 3.44 | 152.00 ± 7.80 | 147.90 ± 5.30 | 136.7 ± 11.1* | 133.4 ± 4.94 | 152.80 ± 3.43 | 149.60 ± 3.66 | 151.70 ± 6.22 | 135.30 ± 7.11 | 144.40 ± 2.67 |
EC50 (μM) | 0.26 (0.28–0.23) | 15.7 (9.32–26.5)* | 0.30 (0.20–0.44) | 1.08 (0.71–6.70)* | 11.9 (9.39–14.3)* | 0.32 (0.30–0.34)*** | 0.31 (0.24–0.41)*** | 2.47 (1.59–3.83)**,*** | 10.6 (2.67–4.19)** | 31.8 (17.1–43.6)**,*** |
fabp1b.1 | ||||||||||
WY14643 | Rosiglitazone | |||||||||
- | GW6471 | T0070907 | Δ5’FR | ΔDR1 | - | GW6471 | T0070907 | Δ5’FR | ΔDR1 | |
E max (RLU) | 152.30 ± 5.57 | 151.30 ± 4.91 | 148.7 ± 5.27 | 146.4 ± 3.52 | 152.80 ± 7.24 | 152.30 ± 5.67 | 148.30 ± 4.87 | 150.70 ± 7.96 | 147.80 ± 2.02 | 178.50 ± 8.68** |
EC50 (μM) | 0.29 (0.17–0.49) | 1.08 (0.86–1.54)* | 0.10 (0.07–0.19) | 0.67 (0.48–0.95) | 28.8 (17.3–48.1)* | 0.11 (0.07–0.15)*** | 0.11 (0.08–0.15)*** | 2.40 (1.39–4.15)**,*** | 0.70 (0.56–0.89)** | 54.5 (32.9–90.4)** |