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Table 3 Sequence similarities in transmembrane domains of Grin1 between different protostomes and H. sapiens

From: Phylogenetic analysis of ionotropic L-glutamate receptor genes in the Bilateria, with special notes on Aplysia californica

Species

TMD1

TMD2

TMD3

A. californica

85%

100%

87%

D. melanogaster

75%

100%

61%

C. elegans

65%

87%

48%

  1. Compared to H. sapiens, Aplysia had fewer amino acid substitutions in transmembrane domains (TMDs) than did D. melanogaster and C. elegans. This points to a higher likelihood of conserved channel function between vertebrates and Aplysia