Figure 4

Negative correlations between EAs and evolutionary rates disappear when EBs are constrained to be even. The data from similar ranges of EBs were grouped together, resulting in 10 different groups. The genes in each group have similar EBs but different ranges of EAs and evolutionary rates. The boxes with nested numbers in the right upper corner (in grey) indicate the groups, and the numbers in the boxes correspond to those in Table S1A of Additional file 2. The lines in each group are derived from linear regression analysis data. All the groups consistently show that the negative correlations between EAs and evolutionary rates are reversed when the EBs are fixed as evenly as possible.