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Table 2 Summary and comparison of pre-miRNA base pairing and nucleotide composition

From: Correlation between sequence conservation and structural thermodynamics of microRNA precursors from human, mouse, and chicken genomes

Species Conservation bp % (A-U) % (A+U) % A % U % G % C %
Human S n (132) 68.66 ± 7.83 42.73 ± 16.12 47.11 ± 13.18 22.10 ± 7.89 25.01 ± 6.96 27.49 ± 7.90 25.40 ± 7.24
  S c 1 (60) 71.88 ± 6.20A 49.34 ± 11.81Ab 53.87 ± 10.66A 23.78 ± 6.36 30.09 ± 6.42A 24.45 ± 5.53AB 21.68 ± 5.84A
  S c 2 (66) 72.94 ± 5.64Ab 48.67 ± 8.17AB 51.62 ± 7.15AB 23.41 ± 4.74B 28.21 ± 4.42AB 25.71 ± 3.49aB 22.67 ± 5.11AB
  S c 3 (33) 73.48 ± 4.67AB 50.14 ± 11.02Ab 52.94 ± 9.67a 22.96 ± 6.05 29.98 ± 6.16A 26.06 ± 5.15B 20.99 ± 5.92A
Mouse S n (108) 67.87 ± 6.51 44.35 ± 11.20 49.30 ± 9.65 22.40 ± 6.16 26.90 ± 5.97 27.28 ± 5.57 23.42 ± 5.74
  S c 1 (63) 72.53 ± 5.85A 48.20 ± 11.47a 53.07 ± 9.42a 23.29 ± 5.42 29.78 ± 6.11A 25.30 ± 5.28a 21.62 ± 5.16a
  S c 2 (75) 72.10 ± 5.87A 47.70 ± 8.14aB 50.57 ± 6.77B 22.90 ± 4.57b 27.67 ± 4.40b 26.28 ± 3.72B 23.15 ± 5.02
  S c 3 (39) 73.37 ± 5.13A 50.85 ± 10.93A 53.05 ± 9.15a 22.89 ± 5.90 30.16 ± 5.51A 26.06 ± 5.06 20.90 ± 5.53a
Chicken* S n (21) 68.24 ± 7.37 37.13 ± 17.43 44.17 ± 14.75 19.47 ± 8.79 24.69 ± 8.01 29.35 ± 6.00 26.48 ± 9.74
  S c 2 (40) 70.89 ± 7.06 51.22 ± 7.19AB 55.11 ± 4.99AB 24.60 ± 4.14B 30.52 ± 3.97AB 24.80 ± 3.53AB 20.08 ± 3.24aB
  S c 3 (19) 73.08 ± 5.14a 53.80 ± 7.56AB 57.18 ± 5.72AB 24.45 ± 5.26 32.74 ± 3.26AB 23.94 ± 4.49A 18.87 ± 3.33AB
  1. Results represent the mean (± SD) of detailed information of base pairing and nucleotide composition. The number of pre-miRNAs within each set is indicated in brackets behind set name. * S c 1 for chicken was excluded as it contained fewer than five pre-miRNAs. Pair-wise comparisons of means (two-sided t-test) and variances (F-test) were performed between non-conserved (S n ) and conserved pre-miRNAs (S c 1, S c 2, and S c 3) from human, mouse, and chicken genomes. a mean value significantly different from that of S n at the 0.05 FDR level. A mean value is significantly different from that of S n at the 0.01 FDR level. b variance is significantly different from that of S n at the 0.05 FDR level. B variance significantly different from that of S n at the 0.01 FDR level.