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Table 3 Divergence of BBS and CCT8L proteins relative to CCT8 proteins

From: Chaperonin genes on the rise: new divergent classes and intense duplication in human and other vertebrate genomes

  MKKS BBS10 BBS12 CCT8L1
No. species2 14 11 11 5
Size (W B )3 5.7770 4.6020 5.8949 3.3859
B-index (B B )4 0.6976 1.1079 1.0284 0.3196
Unbiased pair-wise distance (B B × 2) 1.3952 2.2159 2.0568 0.6393
L B (B B × W B )5 4.0300 5.0987 6.0623 1.0822
Average D ij (D B )6 2.0951 2.9660 3.2858 0.8017
CCT8 7     
Size (W C ) 5.5202 4.5503 4.3647 3.1100
B-index (B C ) 0.1146 0.1373 0.0992 0.0227
Unbiased pair-wise distance (B C × 2) 0.2291 0.2747 0.1983 0.0454
L C (B C × W C ) 0.6324 0.6250 0.4328 0.0706
Average D ij (D C ) 0.3394 0.3687 0.2709 0.0545
B B /B C 6.0873 8.0692 10.3669 14.0793
L B /L C 6.3725 8.1579 14.0072 15.3286
D B /D C 6.1730 8.0445 12.1292 14.7101
W B /W C 1.0465 1.0114 1.3506 1.0887
  1. 1Only the human CCT8L2 branch was included in the tree. The CCT8L1 branch had equivalent length; 2Chaperonin-BBS sequences used in the trees were from the following species (see the legend for Figure 2 for a complete list of abbreviations and species names). MKKS: Bt, Cf, Dr, Ec, Ga, Gg, Hs, Md, Mm, Mmu, Ol, Rn, Tr, Xt; BBS10: Bt, Cf, Dr, Ec, Ga, Hs, Md, Mm, Ol, Rn, Tr; BBS12: Bt, Cf, Dr, Ec, Ga, Gg, Hs, Mm, Ol, Rn, Tr, Xl; CCT8L: Bt, Cf, Hs, Mm, Rn. 3Size is the average number of sequences contained in a cluster over evolutionary time (see Methods); 4The B-index measures the average substitutions per site (evolutionary distance) of the sequences within a cluster from their common ancestor; 5L is the length of the tree (sum of the lengths of all branches); 6Average D ij is the average pair-wise evolutionary distance of the sequences; 7Estimates for CCT8 were computed over corresponding species represented by the sets of MKKS, BBS10, BBS12 or CCT8L proteins (see footnote 2, above).