Figure 4

Malin and TRIM32 are present in vertebrate species. Summary of the results obtained by BLASTP searches and phylogenetic tree constructions. Analyzed species are shown in the left column (in some cases, a whole genus was submitted to BLASTP searches, i.e. Drosophila and Trypanosoma). Species are ordered by kingdoms and taxonomic groups following classification as in [43]. Proteins found in those organisms are marked by a (+) sign (dark grey); undetected proteins are marked as (-) (light grey). Malin and TRIM32 were found in vertebrate species and malin is also present in one cephalochordata genome. Neither of the TRIM proteins analyzed, nor malin, were present in organisms belonging to kingdoms protozoa or chromista, in contrast with the species distribution found for laforin (right column). For a detailed list of protein entries, see additional file 7, Table S2.