Figure 8From: Visualization and Exploration of Conserved Regulatory Modules Using ReXSpecies 2Luciferase assay of the CR1 and CR3 regions. Transactivation activity of Smad3, Stat3 and Klf4 on the conserved regions (CR1 and CR3) was investigated by the dual-glow luciferase assay. Smad3 shows elevated transactivation activity on CR3. Stat3 leads to transcriptional repression on CR1. Klf4 binding results in a repressive effect on CR1 and CR3.Back to article page