Figure 4

Localisation of TLR5 SNPs. Predicted tertiary protein structure of TLR5 and non-synonymous SNPs. A) Predicted tertiary structure of bovine TLR5 and positions of non-synonymous SNPs. 10 amino acid sites correspond to 11 detected SNPs as F679L is affected by two different SNPs in of the same codon. Dashed green circles indicate SNPs occurring at sites of positive selection (L34 and A659); B) Predicted tertiary structure of ovine TLR5 and positions of non-synonymous SNPs. Black backbone depicts putative flagellin binding region; Red amino acids = Non-synonymous SNPs; Dashed green circle indicate SNP occurring at sites of positive selection (A659 corresponding to M659 in sheep).