The relationship between the hierarchical position of proteins in the human signal transduction network and their rate of evolution

Table 2 Comparison of genes occupying extreme upstream and downstream positions in the signaling network

Parameter	Upstream			Downstream			P
Parameter	n	Median	Average	n	Median	Average	P
ω	333	0.076	0.112	249	0.064	0.098	0.037*
d _N	333	0.045	0.070	249	0.037	0.060	0.049*
d _S	333	0.561	0.630	249	0.567	0.626	0.782
Expression level	322	27.32	116.28	243	32.43	165.13	0.239
Expression breadth	322	21.00	15.41	243	23.00	15.84	0.621
ENC	333	50.43	49.36	249	50.36	49.39	0.712
Connectivity	293	6.00	11.86	225	8.00	13.41	0.114
Number of paralogs	333	22.00	36.73	249	28.00	37.63	0.714

ISSN: 2730-7182