Figure 10

Simplified phylogenetic tree showing the catalytic properties of P450s of the DIMBOA-biosynthetic pathway in maize. The first common ancestor probably had the ancestral function of BX2, producing indolin-2- one from indole (in red). This reaction was initially shared with P450s that are not part of the DIMBOA pathway (BX2-like). The duplications leading to the present BX3, 4 and 5 are shown, with each color indicating the presumed conserved catalytic competence of each ancestral enzyme.