Potential

Model

y

x

AIC

<w( AIC)>

N
_{
prot
}

<R>

<pR>


pfANM

Stress

ω

MLmS

190508

0.97

206

0.54

0.33


Flexibility

ω

MSF

198662

0.03

7

0.45

0.06

ANM

Stress

ω

MLmS

194154

0.98

209

0.52

0.39


Flexibility

ω

MSF

207258

0.02

4

0.35

0.04

 NOTE: Potential is the ENM potential, Model is either the Stress Model or Flexibility Model, y is in all cases the sitespecific rate of evolution inferred using Rate4Site, x is the independent variable of each model. AIC is the Akaike Information Criterion summed over all proteins. <w(AIC)> is the average of the AIC weight for each compared model (same ENM). N_{
prot
} is the number of proteins for which each compared model (same ENM) is the best one. <R> is average over proteins of Pearson’s correlation coefficient between variables y and x. <pR> is the average partial correlation coefficient when controlling for the x variable of the contrasting model (same ENM). All variables were zscore normalized for each protein before fitting.