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Table 5 Essential genes missing in LUCA0.9 and their appearance in versions of LUCA with greater g-valuesa

From: Algorithms for computing parsimonious evolutionary scenarios for genome evolution, the last universal common ancestor and dominance of horizontal gene transfer in the evolution of prokaryotes

Gene name COG no. Minimal g-value Function
TRANSLATION AND RIBOSOME BIOGENESIS
GatC COG0721 1.0 Asp-tRNAAsn/Glu-tRNAGln amidotransferase C subunit
LysU COG1190 1.0 Lysyl-tRNA synthetase
GRS1 COG0423 1.5 Glycyl-tRNA synthetase
CENTRAL METABOLIC PATHWAYS AND SUGAR METABOLISM
Glycolysis
PfkA COG0205 1.0 6-phosphofructokinase
Fba COG0191 1.0 Fructose bisphosphate aldolase
GpsA COG0240 1.0 Glycerol 3-phosphate dehydrogenase
GpmA COG0588 2 Phosphoglycerate mutase, cofactor-dependent
TCA cycle   
AcnA COG1048 1.0 Aconitase A
PorG COG1014 1.0 Pyruvate:ferredoxin oxidoreductase
AceF COG0508 1.0 Dihydrolipoamide acyltransferases
FumC COG0114 1.0 Fumarase
TtdA COG1951 3.0 Fumarate hydratase class I, N-terminal domain
FumA COG1838 3.0 Fumarate hydratase class I, C-terminal domain
Pentose phosphate shunt
Zwf COG0364 1.0 Glucose-6-phosphate 1-dehydrogenase
NagB COG0363 1.0 6-phosphogluconolactonase/Glucosamine-6-
MipB COG0176 1.0 Transaldolase
Rpe COG0036 1.0 Pentose-5-phosphate-3-epimerase
RpiA COG0120 1.0 Ribose 5-phosphate isomerase
Gnd COG0362 1.5 6-phosphogluconate dehydrogenase
NUCLEOTIDE METABOLISM
Adk COG0563 1.0 Adenylate kinase and related kinases
Cdd COG0295 1.0 Cytidine deaminase
- COG0590 1.0 Cytosine/adenosine deaminase
DeoC COG0274 1.0 Deoxyribose-phosphate aldolase
Gmk COG0194 1.0 Guanylate kinase
PurS COG1828 1.0 Phosphoribosylformylglycinamidine (FGAM)
THY1 (ThyX) COG1351 1.0 Predicted alternative thymidylate synthase
Pnp COG0005 1.0 Purine nucleoside phosphorylase
PyrH COG0528 1.0 Uridylate kinase
Cmk COG1102 >3 Cytidylate kinase
Tdk COG1435 1.5 Thymidine kinase
AMINO ACID METABOLISM
AroG COG0722 3.0 3-Deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase
AroA COG2876 2.0 3-Deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase
AroD COG0710 1.5 3-dehydroquinate dehydratase
AroQ COG0757 1.5 3-dehydroquinate dehydratase II
AroK COG0703 1.0 Shikimate kinase
TyrB COG1448 3.0 Aspartate/aromatic aminotransferase
HIS2 COG1387 1.0 Histidinol phosphatase and related PHP family phosphatases
  1. aAll data are for the genome-tree topology. Only genes for enzymes of central metabolic pathways are included; genes appearing in LUCA at g >1.5 are indicated by shading