Dayhoff PAM250 plots for ClustalX-aligned N1 (mouse) and N (human) domain amino acid sequence comparisons. At each position in the alignment, the Dayhoff PAM250 log score was determined for pairwise comparisons of each sequence in the mouse set against all sequences in the human set. Mean and standard deviation were calculated for scores at each residue position. Regions representing the CFG face are boxed (1–3) and an RGD-like motif is indicated. Other specified amino acids are denoted by the single letter code. Note that amino acid positions are numbered in vertical orientation.