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Table 7 Animal and yeast clusters

From: Coiled-coil protein composition of 22 proteomes – differences and common themes in subcellular infrastructure and traffic control

Cluster size
(# of sequences)
Max. edge
protein family putative function/site of action organism
57 3.3E-7 Myosin heavy chain XVIII non-muscle and smooth muscle myosins C.e., D.m., H.s., M.m., S.p.
50 6.5E-8 Myosin heavy chain type 2 actin motor protein (cytoskeleton) C.e., D.m., H.s., M.m., S.c., S.p.
27 <E-40 Dynein heavy chain MT motor (cytoskeleton, flagella) C.e., D.m., H.s., M.m., S.c.
17 3.1E-9 Intersectins, Eps15 endocytosis C.e., D.m., H.s., M.m., S.c., S.p.
16 9.5E-7 Png-1, IF-2, Neurofilament triplet L, Troponin T   D.m., H.s., M.m., O.s., S.c.
14 <E-40 Restin, Dynactin, CLIP proteins linking endocytic vesicles to MTs (IF cytoskeleton), dynein activator (MTs in neurons), MT/IF associated (cytoskeleton) C.e., D.m., H.s., M.m., S.c., S.p.
14 1.6E-15 Myosin heavy chain V unusual myosin C.e., D.m., H.s., M.m., S.c.
14 <E-40 DRFs binds Rho-GTP and profilin, promotes actin polymerization (membrane cytoskeleton) D.m., H.s., M.m., S.c.
  1. Numbers include "bridge" sequences qualifying for more than one cluster. Only clusters represented by at least 10 sequences are listed. CLIP, cytoplasmic linker protein [80]; DRFs, diaphanous-related formins [66]; Eps15, epidermal growth factor receptor substrate 15 [125]; Png-1, postmitotic neural gene-1 [126]. For species name abbreviations, see Table 1.