Figure 1

Average per-nucleotide conservation of TATA box and of 10 nucleotides to its left and right. Conservation of all four non-cerevisiae species is pooled together. Grey shading, TATA box; blue solid line, genes sensitive to mutations in DNA binding surface of TBP (N = 213); red dashed line, genes insensitive to mutations in DNA binding surface of TBP (N = 34).