Figure 10From: Tracing the origin of functional and conserved domains in the human proteome: implications for protein evolution at the modular levelCartoon diagram showing the evolution of metalloproteinase family through different stages of evolution. Each central box represents the insertion of a new Pfam-A domain at different evolutionary nodes shown in square brackets. The codes for different nodes are: R, archaea+bacteria; E, eukaryota; T, metazoa; C, chordata. SWISS-PROT identifiers for human protein sequences are given in side boxes along with their domain compositions.Back to article page