Table 2 Some of the functionally known Pfam-A families in each group, defined by the number of nodes associated with it
Number of nodes associated with a group | Pfam-A family ID | Frequency of occurrence in human proteome | Description of the family |
|---|---|---|---|
1 | PF02214 | 120 | K+ channel tetramerization domain |
| Â | PF02101 | 113 | Ocular albinism type 1 protein |
| Â | PF02719 | 112 | Polysaccharide biosynthesis protein |
| Â | PF00307 | 109 | Calponin Homology domain |
| Â | PF04185 | 19 | Phosphoesterase family |
2 | PF02117 | 671 | C. elegans Sra family integral membrane protein |
| Â | PF04762 | 306 | IKI3 family |
| Â | PF00089 | 175 | Trypsin |
| Â | PF00854 | 159 | Proton-dependent oligopeptide transport family |
| Â | PF00969 | 133 | Class II histocompatibility antigen, beta domain |
3 | PF01748 | 923 | C. serpentine receptor like protein |
| Â | PF05462 | 883 | Slime mold cyclic AMP receptor |
| Â | PF00002 | 862 | 7 transmembrane receptor (secretin family) |
| Â | PF03125 | 791 | C. elegans Sre G protein-coupled chemoreceptor |
| Â | PF02118 | 777 | C. elegans Srg family integral membrane protein |
| Â | PF00169 | 307 | Pleckstrin homology domain |
| Â | PF02175 | 305 | C. elegans integral membrane protein Srb |
| Â | PF07653 | 273 | Variant SH3 domain |
4 | PF01461 | 900 | 7 transmembrane chemoreceptor |
| Â | PF03402 | 642 | Vomeronasal organ pheromone receptor family |
| Â | PF01163 | 461 | RIO1 family |
| Â | PF01352 | 461 | Kruppel-associated box domain |
| Â | PF00076 | 313 | RNA recognition motif |
| Â | PF00018 | 288 | SH3 domain |
| Â | PF00046 | 276 | Homeobox domain |
| Â | PF00595 | 210 | PDZ domain |
5 | PF00096 | 1007 | Zinc finger, C2H2 type |
| Â | PF05296 | 917 | Mammalian taste receptor protein (TAS2R) |
| Â | PF00047 | 834 | Immunoglobulin domain |
| Â | PF00069 | 769 | Protein kinase domain |
| Â | PF08205 | 647 | CD80-like C2-set immunoglobulin domain |
| Â | PF07679 | 621 | Immunoglobulin I-set domain |
| Â | PF00071 | 317 | Ras family |
6 | PF03326 | 1403 | Herpes virus transcription activation factor |
| Â | PF07686 | 965 | Immunoglobulin V-set domain |
| Â | PF07714 | 767 | Protein tyrosine kinase |
| Â | PF04388 | 713 | Hamartin protein |
| Â | PF07654 | 489 | Immunoglobulin C1-set domain |
| Â | PF00131 | 344 | Metallothionein |
| Â | PF00023 | 310 | Ankyrin repeat |
| Â | PF00041 | 261 | Fibronectin type III domain |
7 | PF05109 | 2177 | Herpes virus major outer envelope glycoprotein |
| Â | PF03546 | 1859 | Treacher Collins syndrome protein Treacle |
| Â | PF00038 | 1194 | Intermediate filament protein |
| Â | PF00001 | 1004 | 7 transmembrane receptor (rhodopsin family) |
| Â | PF01391 | 277 | Collagen triple helix repeat |
| Â | PF00008 | 221 | Epidermal Growth Factor-like domain |
8 | PF03154 | 3365 | Atrophin-1 family |
| Â | PF04554 | 3125 | Extensin-like region |
| Â | PF03251 | 2546 | Tymo virus 45/70kd protein |
| Â | PF05956 | 2384 | APC basic domain |
| Â | PF01500 | 766 | Keratin, high sulfur B2 protein |