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Table 4 M. leprae PE, PGRS and PPE genes

From: Evolution and expansion of the Mycobacterium tuberculosis PE and PPE multigene families and their association with the duplication of the ESAT-6 (esx) gene cluster regions

PE genes
M. leprae gene number M. leprae gene name* M. tuberculosis orthologue gene number M. tuberculosis orthologue gene name
ML0196c (pseudogene) PE 1 Rv3650 PE33
ML0263c (pseudogene) PE2 Rv1040c PE8
ML0410 PE3 M. leprae-specific -
ML0538 PE4 Rv1386 PE15
ML1053 PE5 Rv1195 PE13
ML1183c PE6 M. leprae-specific paralogue of Rv1195 -
ML1493 (pseudogene) PE7 Rv1172c PE12
ML1534c (pseudogene) PE8 Rv1806 PE20
ML1743c (pseudogene) PE9 M. leprae-specific -
ML2534c PE10 Rv0285 PE5
ML2632 (pseudogene) PE11 Rv0160c PE4
ML1865c (pseudogene) - M. leprae-specific -
ML2129c (pseudogene) - M. leprae-specific -
ML 2477 (pseudogene) - Rv3746c PE34
PE_PGRS genes
M. leprae gene number M. leprae gene name* M. tuberculosis orthologue gene number M. tuberculosis orthologue gene name
ML0194c (pseudogene) PE_PGRS1 Rv3653 PE_PGRS61
ML0495 (pseudogene) PE_PGRS2 M. leprae-specific -
ML1092c (pseudogene) PE_PGRS3 Rv1243c PE_PGRS23
ML1403 (pseudogene) PE_PGRS4 Rv1651c PE_PGRS30
ML1414 (pseudogene) PE_PGRS5 M. leprae-specific -
ML2241c (pseudogene) PE_PGRS6 Rv0754 PE_PGRS11
ML0147 (pseudogene) - M. leprae-specific -
ML0946 - M. leprae-specific -
PPE genes
M. leprae gene number M. leprae gene name* M. tuberculosis orthologue gene number M. tuberculosis orthologue gene name
ML0026 (pseudogene) PPE1 M. leprae-specific -
ML0277 (pseudogene) PPE2 Rv0388c PPE9
ML0328c (pseudogene) PPE3 M. leprae-specific paralogue of Rv3021c paralogue of PPE47
ML0503 (pseudogene) PPE4 M. leprae-specific -
ML0539 PPE5 Rv1387 PPE20
ML0797c (pseudogene) PPE6 M. leprae-specific -
ML0828 (pseudogene) PPE7 Rv2352c PPE38
ML1054 (pseudogene) PPE8 Rv1196 PPE18
ML1182c PPE9 M. leprae-specific paralogue of Rv1196 -
ML1308c (pseudogene) PPE10 Rv2123 PPE37
ML1533c (pseudogene) PPE11 Rv1807 PPE31
ML1828c PPE12 Rv0256c PPE2
ML1991 PPE13 Rv0096 PPE1
ML2369c (pseudogene) PPE14 Rv0442c PPE10
ML2533c (pseudogene) PPE15 Rv0286 PPE4
ML2538c (pseudogene) PPE16 M. leprae-specific, situated between Rv0281 and 82 -
ML0051c PPE68 Rv3873 PPE68
ML0411 - M. leprae-specific -
not annotated, situated between ML0262c and 63c (pseudogene) - Rv1039c PPE15
ML1754 (pseudogene) - Rv1361c PPE19
ML0588 - M. leprae-specific -
ML1935c (pseudogene) - M. leprae-specific -
ML1967c (pseudogene) - M. leprae-specific -
ML1968c (pseudogene) - M. leprae-specific -
ML2128c (pseudogene) - M. leprae-specific -
ML2243c (pseudogene) - M. leprae-specific -
  1. * Regrettably, and in contrast to the annotation of the PE and PPE genes in M. bovis, the genes in M. leprae are annotated according to their own PE and PPE numbers and not according to the same numbers as its corresponding orthologue in M. tuberculosis, with the only exception being PPE68 which have the same name in both species.