Figure 2
From: Multiple domain insertions and losses in the evolution of the Rab prenylation complex
(A) taxonomic tree of the organisms analyzed in this study, adapted from the NCBI's taxonomy database [73] and from reference [28] (B) N- to C-terminal domain organization of the α-subunit of RGGTase. Boxes with the same shape represent the same domain, whereas different shapes represent distinct domains. Green boxes represent tetratricopeptide repeats (TPRs). In between the 5th and 6th TPR some proteins display an inserted domain. In deuterostomes this is a C2-like domain (inverted orange triangle), but in other organisms the inserted sequences are not recognized as any known domain. They are represented by colored lines. Inserts of the same color are similar to each other. Ellipses represent LRR domains – distinct colors represent sequence similarity. The red circle with 2× on the left indicates that this protein is duplicated in that organism. (C) N- to C-terminal domain organization of REP. The blue boxes represent the Sequence Conserved Regions (SCRs) between SCR1 and SCR2 there is an inserted domain of unknown structure. This domain is only conserved within taxa: all the inserted sequences represented in yellow are similar to each other but distinct from all other inserted sequences represented in other colors. (D) N- to C-terminal domain organization of the β-subunit The gray boxes represent the prenyltransferase and squalene oxidase repeat.