Figure 2

Comparison between Human and axolotl p53 important domains, regions and residues. (A) Schematic structure of p53 protein (adapted from Appella, 2001 [71]): TA, Transactivation Domain; DBD, DNA Binding Domain; NLS, Nuclear Localisation Signal; TET, tetramerisation domain; REG, Regulatory domain; Regions I-V, highly conserved regions. Lysine (K), serine (S) and threonine (T) residues implicated in post-translational modifications are indicated. The protein domains depicted in the diagrams are not to scale. (B) Sequences alignment of human and axolotl p53 proteins. The conserved regions I to V are highlighted and many changes between the axolotl and human sequence are identified (arrows). See table-2 for a complete list of changes associated with mutations in the human protein.