Figure 3

Frequencies of inserted and deleted amino acids. a) Frequency distribution of inserted/deleted amino acids resulting from coding indels in our set compared to the background amino acid frequencies in all human proteins. b) Frequencies of inserted/deleted amino acids grouped according to 10 different physio-chemical categories. Notice that amino acids can be assigned to more than one category. Error bars in a) and b) are standard deviations calculated by , where N _i is the total number of inserted/deleted amino acids i, or amino acids in category i, respectively.