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Table 3 Z-scores of free energy. Comparison between each real pre-miRNA and 1,000 random and four types of shuffled sequences.

From: In silico genetic robustness analysis of microRNA secondary structures: potential evidence of congruent evolution in microRNA

Species Random Zero-markov Mononucleotide First-markov Dinucleotide
H. sapiens -3.96 ± 1.27 -4.31 ± 1.40 -4.36 ± 1.40 -6.05 ± 1.85 -5.63 ± 1.87
C. elegans -2.51 ± 1.52 -3.34 ± 1.45 -3.37 ± 1.46 -4.85 ± 2.18 -4.87 ± 2.09
D. melanogaster -2.30 ± 1.05 -3.53 ± 1.08 -3.53 ± 1.08 -4.83 ± 1.51 -4.85 ± 1.56
D. rerio -2.87 ± 1.33 -3.53 ± 1.19 -3.64 ± 1.23 -4.91 ± 1.69 -4.67 ± 1.64
M. musculus -3.63 ± 1.25 -3.89 ± 1.40 -3.87 ± 1.34 -5.41 ± 1.83 -4.95 ± 1.84
R. norvegicus -3.68 ± 1.33 -3.60 ± 1.30 -3.68 ± 1.33 -5.25 ± 1.80 -4.80 ± 1.86
Average -3.26 ± 1.42 -3.75 ± 1.35 -3.81 ± 1.35 -5.28 ± 1.86 -4.98 ± 1.83