From: Mutation patterns of mtDNA: Empirical inferences for the coding region
Reference | Region | Method | Human-chimpanzee divergence time (Myr) | Substitution rate as expressed by authors | Standardized substitution rate mutations/site/Myra |
---|---|---|---|---|---|
Horai et al. [27] | Synonymous positions | Phylogenetic | 4.9 | 3.89 × 10-8 mut/site/year | 0.0389 |
Kivisild et al. [29] | 4212 synonymous positions | Phylogenetic | 6 | 3.5 × 10-8 transversions/site/year | 0.035 |
Kivisild et al. [29] | Synonymous positions | Phylogenetic | 6 | 2.1 × 10-9 transversions/site/year | 0.0021 |
Kivisild et al. [29] | rRNA positions | Phylogenetic | 6 | 4.1 × 10-10 transversions/site/year | 0.00041 |
Cann et al. [19] | Complete mtDNA | Phylogenetic | - | 0.01–0.02 mut/site/Myr | 0.01–0.02 |
Torroni et al. [26] | Complete mtDNA | Phylogenetic | - | 0.00022–0.00029 mut/site/10000 | 0.022–0.029 |
Brown [18] | Complete mtDNA | Phylogenetic | - | 0.005–0.01 mut/site/Myr | 0.005–0.01 |
Vigilant et al. 1991 | HVR I and II | Phylogenetic | 6 | 17.3%/Myr | 0.0865 |
Tamura and Nei 1993 | HVR I and II | Phylogenetic | 4–6 Myr | 1.5×10-7-2.5×10-8/site/year | 0.1500–0.0250 |
Pesole et al. 1992 | HVR I and II | Phylogenetic | 7.5 Myr | 18 ± 10/100 site/Myr | 0.1800 ± 0.1 |
Ho et al. [41] | D-loop | Population (calibration 80 kyr) | - | 0.197 (0.115–0.293) mut/site/Myr | 0.197 (0.115–0.293) |
Santos et al. [37](1) | D-loop | Pedigree | - | 3.5219×10-5/site/generation | 1.4088 |
Santos et al. [37](2) | D-loop | Pedigree | - | 1.9210×10-5/site/generation | 0.7684 |
Santos et al. [37](4) | D-loop | Pedigree | - | 1.2807×10-5/site/generation | 0.5123 |
Santos et al. [37](6) | D-loop | Pedigree | - | 4.1878×10-6/site/generation | 0.1675 |
Heyer et al. [36]c | HVR I and II | Pedigree | - | 11.7/site/million generations | 0.4680 |
Sigurðardóttir et al [34]c | HVR I and II | Pedigree | - | 0.32/site/Myr | 0.2529 |
Parsons et al [32](1) | HVR I and II | Pedigree | - | 2.5/site/Myr | 1.7957 |
Howell et al [31]d (2) | D-loop | Pedigree | - | 9.48×10-6 mut/site/generation | 0.3791 |
Mishmar et al. [2] | Coding region | Phylogenetic | 6.5 | 1.26 × 10-8 mut/site/year | 0.0126 |
Ingman et al. [28] | Coding region | Phylogenetic | 5 | 1.70 × 10-8 mut/site/year | 0.017 |
Howell et al. [31](2) | Coding regionb | Pedigree | - | 1.52 × 10-6 mut/site/generation | 0.0609 |
Present study (1) | 1102 bp Coding region | Pedigree | - | 8.75 × 10-6 mut/site/generation | 0.3501 |
Present study (2) | 1102 bp Coding region | Pedigree | - | 5.84 × 10-6 mut/site/generation | 0.2334 |
Present study (3) | 1102 bp Coding region | Pedigree | - | 8.75 × 10-6 mut/site/generation | 0.3501 |
Present study (4) | 1102 bp Coding region | Pedigree | - | 5.84 × 10-6 mut/site/generation | 0.2334 |
Present study (5) | 1102 bp Coding region | Pedigree | - | 1.03 × 10-6 mut/site/generation | 0.0411 |
Present study (6) | 1102 bp Coding region | Pedigree | - | 5.89 × 10-7 mut/site/generation | 0.0236 |
Present study (7) | 1102 bp Coding region | Pedigree | - | 4.39 × 10-7 – 4.97 × 10-7 mut/site/generation | 0.0176–0.0199 |
Present study (8) | 1102 bp Coding region | Pedigree | - | 0–5.84 × 10-8 mut/site/generation | 0–0.0023 |