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Table 2 Interacting clusters formed between PSGs on each lineage

From: The role of positive selection in determining the molecular cause of species differences in disease

Cluster
number
Genes
in cluster
pvalue for cluster size
given previous clusters
pvalue for cluster given
number of interactions per gene **
Chimpanzee    
1 PCSK5, BMP4, PHOX2A 0.981 0.0013
2 LHB, OTX1, JUB 0.391 0.0001
3 XPC, RAD23A 0.519 0.0035
4 NUCB1, PTGS1 0.346 0.0046
5 ITGB6, ALOX12 0.227 0.0030
6 MYO18A, TRADD 0.131 0.0028
7 GSTP1, MAP2K4 0.075 0.0442
8 PEX12, PEX19 0.036* 0.0003
9 NRP1, MSI1 0.019* 0.0008
Dog    
1 CFP, TAL1, SERPINB1, MMP12, PRF1, BCL2, HRG, ITGA5, COMP 0.385 < 0.0001
2 CD79A, HCLS1, LCP2 0.209 0.0012
3 SNTA1, DAG1, MUSK 0.036* 0.0002
4 LRP5, SLC2A2 0.171 0.0026
5 ALB, MCAM 0.082 0.0123
Hominid    
1 CCL19, CD86, MADCAM1 0.335 0.0015
2 MRC2, COL4A4 0.186 0.0028
3 DRD2, TH 0.045* 0.0488
4 ITGAV, AZGP1 0.008* 0.0080
Mouse    
1 HLA-DRB1, HLA-DQA2 0.755 0.0123
2 C1R, C1QA 0.288 0.0030
Murid    
1 TLR5, CD86, PTGIR 0.678 0.0001
2 SCNN1G, SPTA1, HECW1 0.432 0.0021
3 CNR1, RAPGEF1 0.190 0.0110
4 F5, GP1BA 0.064 0.0032
Rat    
1 CDKN2D, TRIM21, CDKN1B, CAST, ICAM1, CFD, ITGB2, C3 0.360 < 0.0001
2 KCNA4, ACTN2, PIK3R5 0.526 0.0016
3 PIM1, RP9 0.280 0.0063
4 ASPH, HDAC4 0.118 0.0053
  1. *p < 0.05.
  2. ** All tests to investigate if the size of the cluster would be more than expected by chance given the number of interactors each individual gene in that cluster were significant (p < 0.05).