(A) Tetrapod Myoglobin



MI

NMI

RMI

SCA

MIP
  


p ≤ α

p > α

p ≤ α

p > α

p ≤ α

p > α

p ≤ α

p > α

p ≤ α

p > α

χ
^{2}

p – value


(i,i+3)

2

51

9

44

0

53

10

43

11

42

17.98

1.24 × 10^{3}

(i,i+4)

32

21

41

12

1

52

36

17

18

35

79.28

2.48 × 10
^{16}

(B) Randomized Tetrapod Myoglobin


MI

NMI

RMI

SCA

MIP
  

p ≤ α

p > α

p ≤ α

p > α

p ≤ α

p > α

p ≤ α

p > α

p ≤ α

p > α

χ
^{2}

p – value

(i,i+3)

4

49

0

53

0

53

0

53

0

53

16.25

2.71 × 10
^{3}

(i,i+4)

0

53

0

53

0

53

0

53

1

52

4.02

4.04 × 10^{1}

(C) Chordate Myosin


MI

NMI

RMI

SCA

MIP
  

p ≤ α

p > α

p ≤ α

p > α

p ≤ α

p > α

p ≤ α

p > α

p ≤ α

p > α

χ
^{2}

p – value

(i,i+3)

51

2

46

7

38

15

40

13

46

7

14.83

5.08 × 10
^{3}

(i,i+4)

52

1

44

9

26

27

44

9

43

10

41.30

2.33 × 10
^{8}

(D) Randomized Chordate Myosin


MI

NMI

RMI

SCA

MIP
  

p ≤ α

p > α

p ≤ α

p > α

p ≤ α

p > α

p ≤ α

p > α

p ≤ α

p > α

χ
^{2}

p – value

(i,i+3)

5

48

18

35

4

49

2

51

27

26

53.30

7.38 × 10
^{11}

(i,i+4)

0

53

0

53

0

53

0

53

0

53

n/a

n/a

 χ^{2} goodnessoffit tests comparing the performance of treeignorant methods for detecting alpha helix periodicity at (i, i + 3) and (i, i + 4). Bolded rows highlight statistically significant χ^{2} results, indicating a difference between the methods. Bold counts in these rows highlight which method achieved the highest ratio of significant to insignificant scores. Counts are calculated using the empirically determined optimal SCA cutoff for each positive control data point. SCA cutoff is 0.9 for AB row 1, 0.8 for AB row 2, 0.4 for CD row 1, and 0.6 for CD row 2. α = 0.01.