Figure 3

Genotypic canalization. A Evolution of average, population level phenotypic distances (left), genome distances (middle) and network distances (right) under sexual (red lines) and asexual (black lines) reproduction. For an explanation of the measures used see Methods. B and C In the cartoon we show two different, simplified genomes and the genome sequences resulting from a pairwise alignment of these two sequences. Note the introduction of alignment gaps (grey). Next, we show these aligned sequences again if only the genes but not the TFBS (left) are displayed, or if only the upstream regulatory region (URR) with TFBS but not the genes themselves (right) are shown. B Data: Aligned genomes with only genes shown. Multiple sequence alignment is performed using Clustalw (see Methods). Genomes shown are for the same individuals as in Figure 2E, and are again clustered based on phenotype. Grey: alignment gaps; color: genes of different types. C Data: Aligned genomes with only the URRs with their TFBS shown. Genomes shown are the same as in B and are clustered based on phenotype. We show a maximum of 3 TFBS per gene. Grey: alignment gaps and absent TFBS (if a gene has less than 3 TFBS); color: TFBS of different type and weight.