Long-range regulation is a major driving force in maintaining genome integrity

Table 4 Percentage of susceptible, neutral and refractory regions covered by rare, common fragile sites and CNVs.

	% covered by rare fragile sites	% covered by common fragile sites	% covered by CNVs
Susceptible regions	8.8	24.7	25.1
Neutral regions	4.5	22.3	22.3
Refractory regions	5.5	20.7	19.6

The statistical significance of the enrichment between refractory and susceptible regions for rare and common fragile sites as well as CNVs regions was assessed with a permutation test. The resulting p-values are < 10^-4

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