Table 2 Testing simultaneously for consistent within-species and within-lineage variations in nucleotide substitution rates (N: non-synonymous, S: synonymous) of the MHC-DRB molecule at different regions (ABS: contact residues, non-ABS: non-contact residues).
All lineages | Species-specific effects | Lineage-specific effects |
|---|---|---|
dN, ABS | F42,91 = 2.311, P < 0.001 | F59,89 = 1.875, P = 0.004 |
dS, ABS | F42,91 = 1.809, P = 0.010 | F59,89 = 1.572, P = 0.026 |
dN, non-ABS | F42,91 = 1.491, P = 0.058 | F59,89 = 1.490, P = 0.044 |
dS, non-ABS | F42,91 = 1.690, P = 0.019 | F59,89 = 2.628, P < 0.001 |
dN, all sites | F42,91 = 2.120, P = 0.002 | F59,89 = 1.694, P = 0.012 |
dS, all sites | F42,91 = 1.908, P = 0.005 | F59,89 = 2.135, P < 0.001 |
Only HLA orthologous | Species-specific effects | Lineage-specific effects |
dN, ABS | F20,18 = 3.152, P = 0.009 | F16,18 = 1.155, P = 0.381 |
dS, ABS | F20,18 = 1.632, P = 0.150 | F16,18 = 0.356, P = 0.979 |
dN, non-ABS | F20,18 = 2.253, P = 0.044 | F16,18 = 1.104, P = 0.417 |
dS, non-ABS | F20,18 = 3.058, P = 0.010 | F16,18 = 0.878, P = 0.601 |
dN, all sites | F20,18 = 3.347, P = 0.006 | F16,18 = 0.986, P = 0.507 |
dS, all sites | F20,18 = 2.842, P = 0.015 | F16,18 = 0.645, P = 0.809 |