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Table 1 Sequence information of homologues of RIG-I, MDA5, LGP2, DICER and eIF4A in vertebrates and invertebrates

From: Origin and evolution of the RIG-I like RNA helicase gene family

Gene name ENSEMBL prediction ID GenBank GI EST Protein length Identity/similarity to human homologue
RIG-I     
Human ENSG00000107201 NM_014314 925 100/100
Xenopus ENSXETG00000009200   945 43.6/64.2
Zebrafish ENSDARG00000039785   628 25.9/41.3
MDA5     
Human ENSG00000115267 NM_022168 1025 100/100
Chicken ENSGALG00000011089 XM_422031 1285 47.8/58.8
Xenopus ENSXETG00000013176   1003 53.3/69.2
Zebrafish ENSDARG00000018553 XM_689032 1219 34.5/52.4
Stickleback ENSGACG00000005518   1008 47.1/64.3
Medaka ENSORLG00000016902   987 47/65.9
Fugu ENSTRUG00000001413   1000 44.7/63
Tetraodon ENSTNIG00000016500   1038 42.6/63
LGP2     
Human ENSG00000108771 NM_024119 678 100/100
Chicken ENSGALG00000023821   588 43.6/59.1
Xenopus ENSXETG00000002302   588 46.8/61.8
Zebrafish ENSDARG00000070935 XM_001920601 682 40.8/62.5
Stickleback ENSGACG00000008740   681 47.2/68.9
Medaka ENSORLG00000003825   673 47.4/66.1
Fugu ENSTRUG00000015710   671 46.2/64.7
Tetraodon ENSTNIG00000011713   680 47.7/65.9
DICER     
Human ENSG00000100697 NM_177438 1922 100/100
Chicken ENSGALG00000010999 NM_001040465 1921 92.0/96.0
Xenopus ENSXETG00000023315   422 18.9/20.6
Zebrafish ENSDARG00000001129 XM_678382 1975 75.5/84.4
Stickleback ENSGACG00000020134   1901 75.9/84.5
Medaka ENSORLG00000011022   1905 76.5/85.2
Fugu ENSTRUG00000006156   1896 75.8/84.4
Tetraodon ENSTNIG00000005441   1915 75.8/85.0
Sea urchin DICER   XM_785801 1850 41.0/60.1
Caenorhabditis elegans DRH1 F15B10.2 NM_068617 1037 14.2/27.5
Caenorhabditis elegans DRH2 C01B10.1   956 14.4/26.1
Caenorhabditis elegans DRH3 D2005.5 NM_059760 1119 15.8/28.7
Caenorhabditis elegans DCR1 K12H4.8 NM_066360 1845 33.7/53.3
Drosophila DCR1   NM_079729 2249 32.0/50.1
Jewel wasp DICER1   XM_001605237 1917 37.3/59.5
eIF4A     
Human eIF4A1 ENSG00000161960 BT019879 407 100/100
Chicken eIF4A2   NM_204549 407 90.4/96.3
Xenopus eIF4A ENSXETG00000020123 NM_001011139 406 94.8/98.5
Zebrafish eIF4A1a ENSDARG00000040268 NM_198366 406 89.4/96.8
Zebrafish eIF4A1b ENSDARG00000003032 NM_201510 406 89.2/97.1
Stickleback eIF4A1 ENSGACG00000020072   406 89.7/97.3
Medaka eIF4A1 ENSORLG00000010659   405 89.7/97.3
Fugu eIF4A1 ENSTRUG00000002188   406 78.9/90.4
  ENSTRUG00000017170   408 63.9/81.6
  ENSTRUG00000011113   411 62.6/80.5
Tetraodon eIF4A1 ENSTNIG00000004408   292 55.6/64.9
  ENSTNIG00000017079   352 60.7/73.5
  ENSTNIG00000006865   384 68.1/84.3
  ENSTNIG00000007405   411 69.2/87.1
  ENSTNIG00000004366   316 55.4/66.8
  ENSTNIG00000000303   339 47.7/64.6
Drosophila eIF4A FBgn0001942 NM_164668 403 72.1/86.7
   NM_164669   
   NM_057247   
   NM_164670   
Sclerotinia sclerotiorum eIF4A   XM_001594601 398 74.7/86.5
Botryotinia fuckeliana eIF4A   XM_001561331 398 74.4/86.5
Invertebrate RIG-I like genes     
Sea urchin RIG-I (LOC591972) NW_001470282 XM_791516 960 26.4/47.8
Sea urchin RIG-I (LOC575036) NW_001312424 XM_001176480 823 23.8/43.2
Sea urchin RIG-I (LOC767124) NW_001297703 XM_001203626 303 11.8/19.2
Sea urchin RIG-I (LOC574972) NW_001312424 XM_775381 968 29.3/50.3
Sea urchin RNA helicase (LOC593153)   XM_792644 996 21.4/41.0
Sea urchin RNA helicase (LOC583008)   XM_001198571 480 16.1/26.4
Sea urchin RIG-I   XM_778463 927 28.7/49.7
Sea urchin RNA helicase (LOC578749)   XM_778903 870 27.2/48.6
Sea urchin RIG-I (LOC582062)   XM_782035 209 10.7/14.5
Sea urchin RIG-I (LOC577076)   XM_777329 1051 19.9/39.7
Nematostella vectensis RIG-I/MDA5 like gene 1   XM_001636292 XP_001636342 672 26.3/41.0
Nematostella vectensis RIG-I/MDA5 like gene 2   XM_001639190 XP_001639240 689 25.5/41.7