Fig. 4

Potential active site configurations for five CYP71AJ groups. The homology models were constructed in CPHmodels-3.2 and VOIDOO was used for cavity calculations. SRS1: blue; SRS2 + 3: green; SRS4: yellow; SRS5: orange; SRS6: red; and heme-group: grey. The three-amino-acid motives in SRS1 that are likely important for substrate acceptance are indicated with dashed ovals. Residue differences between groups II-5 and II-6 are marked with black. Other residue likely to be important for the active sites are discussed in the text. a) CYP71AJ3, b) CYP71AJ4, c) CYP71AJ6 and CYP71AJ12, d) CYP71AJ32