Evolution of the avian β-defensin and cathelicidin genes

Cheng, Yuanyuan; Prickett, Michael Dennis; Gutowska, Weronika; Kuo, Richard; Belov, Katherine; Burt, David W.

doi:10.1186/s12862-015-0465-3

BMC Ecology and Evolution

Table 3 Mean rates of synonymous (d_S ± S.E.) and nonsynonymous (d_N ± S.E.) nucleotide substitutions and test for overall selection in β defensin and cathelicidin genes

From: Evolution of the avian β-defensin and cathelicidin genes

Gene	Signal peptide & propiece					Mature peptide
Gene	d_S	d_N	d_N − d_S	Stat^b	P^c	d_S	d_N	d_N − d_S	Stat^b	P^c
AvBD1	0.338 ± 0.061	0.175 ± 0.035	−0.162 ± 0.062	2.623	0.005	0.585 ± 0.073	0.347 ± 0.068	−0.237 ± 0.094	2.494	0.007
AvBD2	0.223 ± 0.033	0.060 ± 0.015	−0.163 ± 0.034	4.450	0.000	0.288 ± 0.032	0.147 ± 0.030	−0.141 ± 0.046	3.102	0.001
AvBD3	0.250 ± 0.052	0.139 ± 0.034	−0.111 ± 0.045	2.495	0.007	0.690 ± 0.048	0.534 ± 0.088	−0.155 ± 0.092	1.699	0.046
AvBD4	0.210 ± 0.039	0.205 ± 0.036	−0.005 ± 0.040	0.117	0.453	0.319 ± 0.061	0.176 ± 0.042	−0.143 ± 0.068	2.183	0.016
AvBD5	0.216 ± 0.045	0.143 ± 0.029	−0.073 ± 0.053	1.401	0.082	0.473 ± 0.055	0.098 ± 0.022	−0.376 ± 0.060	6.476	0.000
AvBD7	0.194 ± 0.049	0.147 ± 0.037	−0.047 ± 0.066	0.708	0.240	0.396 ± 0.057	0.227 ± 0.046	−0.169 ± 0.072	2.377	0.010
AvBD8	0.226 ± 0.045	0.095 ± 0.021	−0.131 ± 0.052	2.529	0.006	0.446 ± 0.043	0.121 ± 0.024	−0.325 ± 0.049	6.715	0.000
AvBD9	0.152 ± 0.038	0.053 ± 0.017	−0.098 ± 0.040	2.552	0.006	0.317 ± 0.061	0.090 ± 0.018	−0.227 ± 0.056	4.025	0.000
AvBD10	0.191 ± 0.044	0.106 ± 0.024	−0.085 ± 0.059	1.461	0.073	0.361 ± 0.051	0.117 ± 0.026	−0.244 ± 0.054	4.612	0.000
AvBD11	0.164 ± 0.054	0.069 ± 0.015	−0.095 ± 0.059	1.670	0.049	0.362 ± 0.037	0.088 ± 0.013	−0.274 ± 0.040	6.450	0.000
AvBD12	0.281 ± 0.048	0.171 ± 0.043	−0.108 ± 0.056	1.895	0.030	0.334 ± 0.053	0.115 ± 0.022	−0.219 ± 0.056	3.752	0.000
AvBD13	0.222 ± 0.050	0.108 ± 0.023	−0.114 ± 0.057	2.135	0.017	0.249 ± 0.044	0.059 ± 0.013	−0.190 ± 0.042	4.547	0.000
AvBD14	0.351 ± 0.071	0.263 ± 0.044	−0.087 ± 0.079	1.099	0.137	0.309 ± 0.054	0.137 ± 0.025	−0.172 ± 0.055	3.029	0.002
DEFB1^a	0.072 ± 0.039	0.023 ± 0.008	−0.049 ± 0.040	1.261	0.105	0.097 ± 0.041	0.040 ± 0.020	−0.058 ± 0.039	1.467	0.072
DEFB4^a	0.054 ± 0.034	0.029 ± 0.016	−0.025 ± 0.041	0.622	0.268	0.158 ± 0.049	0.143 ± 0.030	−0.016 ± 0.057	0.283	0.389
CATHL2	0.417 ± 0.051	0.162 ± 0.023	−0.255 ± 0.053	4.756	0.000	0.401 ± 0.082	0.267 ± 0.054	−0.134 ± 0.095	1.416	0.080
CATHL3	0.310 ± 0.047	0.187 ± 0.026	−0.123 ± 0.052	2.448	0.008	0.379 ± 0.095	0.247 ± 0.051	−0.132 ± 0.095	1.372	0.086
CATHB1	0.448 ± 0.039	0.300 ± 0.024	−0.148 ± 0.043	3.362	0.001	0.508 ± 0.074	0.508 ± 0.057	0.001 ± 0.090	0.006^d	0.497^d
CAMP^a	0.095 ± 0.015	0.063 ± 0.008	−0.032 ± 0.017	1.852	0.033	0.066 ± 0.018	0.216 ± 0.039	0.157 ± 0.041	3.906^d	0.000 ^d

^a Primate genes
^b Z-test statistic for purifying selection (d_S > d_N)
^c Values of P < 0.05 are considered significant (in bold)
^d Tested for positive selection (d_S < d_N)

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