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Fig. 3 | BMC Evolutionary Biology

Fig. 3

From: A comparison of human and mouse gene co-expression networks reveals conservation and divergence at the tissue, pathway and disease levels

Fig. 3

Evaluation of conservation of 22 pathway-specific gene sets selected from the Reactome database. For the explanation of the statistical tests and plots refer to Fig. 2, Additional file 2: Figure S5 and Methods. The pathways have been manually selected for their relevance in the context of this manuscript. For the complete result table refer to the Additional file 5 that includes the analysis on gene sets retrieved from eight databases. The pathways are ranked according to the level of conservation in terms of common co-expression (a). The olfactory pathway is the most diverged in mice when looking at the differential connectivity plot (b). Even though the cell cycle process and DNA replication are generally conserved, there are related processes, such as packaging of telomere ends and RNA Polymerase I promoter opening, that are systematically diverged for different aspects (a, c and d). Although the lipoprotein metabolism is conserved in terms of the co-expression patterns (a), it has an increased connectivity in mouse that does not reach the required significance (b); nevertheless, one of its descending pathways, HDL-mediated lipid transport produced highly significant results (Additional file 5) that defined the genes that mostly contribute to this divergence

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