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Table 1 Data summary. The relative fitness, number of fitness determinations, epistasis coefficient, and the Hamming distance to the WT folding obtained with the RNAdistance program are shown for each genotype. Errors represent ±1 SEM

From: Distribution of mutational fitness effects and of epistasis in the 5’ untranslated region of a plant RNA virus

Mutant genotype Relative fitness Number Epistasis Hamming distance
WT 1.000 ± 0.006 15   
A16G 0.918 ± 0.033 24   66
C18A 0.958 ± 0.042 12   0
C23G 0.962 ± 0.029 21   16
A24U 0.878 ± 0.057 21   0
A37G 0.861 ± 0.032 15   32
G39U 0.915 ± 0.033 30   0
A46U 0.910 ± 0.042 21   8
A54G 0.823 ± 0.058 21   49
C57U 0.808 ± 0.052 15   4
G75U 0.802 ± 0.061 18   47
A83G 0.927 ± 0.055 10   53
A84G 0.866 ± 0.037 35   10
C91U 0.913 ± 0.033 32   0
C100G 0 30   48
C106U 0.896 ± 0.051 24   37
C127U 0 30   53
U131C 0.997 ± 0.023 15   0
A135G 0.971 ± 0.033 27   7
G138U 0.985 ± 0.023 24   2
G142A 0.873 ± 0.038 27   32
A16G/C23G 0.999 ± 0.024 24 0.117 ± 0.089 40
A16G/C100G 0.902 ± 0.042 27 0.903 ± 0.048 33
A16G/C127U 0 30 0 53
A16G/A135G 1.012 ± 0.020 21 0.120 ± 0.089 7
C18A/C100G 0 30 0 48
C23G/A24U 0.932 ± 0.034 21 0.088 ± 0.120 10
C23G/A54G 1.040 ± 0.005 3 0.250 ± 0.091 57
C23G/142A 0 30 −0.839 ± 0.062 40
A24U/C106U 1.031 ± 0.056 21 0.244 ± 0.159 37
A37G/C106U 0.899 ± 0.024 21 0.127 ± 0.102 18
A37G/A135G 0.956 ± 0.004 30 0.120 ± 0.070 7
G39U/C91U 0.901 ± 0.032 27 0.066 ± 0.098 0
A46U/A135G 0.900 ± 0.013 32 0.017 ± 0.090 15
C57U/G75U 0.906 ± 0.039 30 0.259 ± 0.135 8
C57U/A83G 0.823 ± 0.052 9 0.074 ± 0.150 45
C57U/C127U 0.949 ± 0.037 27 0.949 ± 0.043 35
A83G/C100G 1.019 ± 0.019 18 1.019 ± 0.026 53
A84G/G142A 0.999 ± 0.014 24 0.244 ± 0.086 32
C91U/U131C 1.016 ± 0.015 30 0.106 ± 0.075 0
C91U/A135G 0.833 ± 0.007 3 −0.053 ± 0.074 7
C100G/C106U 0.751 ± 0.035 11 0.751 ± 0.040 48
C100G/G138U 0.635 ± 0.002 3 0.635 ± 0.006 33
C127U/A135G 0.816 ± 0.077 6 0.817 ± 0.082 7
U131C/G142A 0.705 ± 0.048 6 −0.166 ± 0.111 20
A135G/G138U 0 10 −0.957 ± 0.055 9