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Fig. 3 | BMC Evolutionary Biology

Fig. 3

From: Adaptive patterns in the p53 protein sequence of the hypoxia- and cancer-tolerant blind mole rat Spalax

Fig. 3

Model of Spalax p53 N-terminal (p53N) interaction with: a RPA70 repair protein. Left – Crystal structure of human p53N fragment (33–60) bound to RPA70N (PDBID 2B3G). The p53 fragment is depicted as a cyan helix and RPA70N as an electrostatic surface (upper panel) or as green ribbons (lower panel). Right – Model of the Spalax p53–RPA70 complex, based on the human complex. b P300 co-activator. Upper panel - The structure of human p53N bound to p300 (PDBID 2MZD). Lower panel - Model of the Spalax p53–p300 complex, based on the human complex. From this analysis, it seems that the human p53 interface with RPA70 and P300 involves more hydrophobic and ionic interactions than the Spalax interface, making the complexes more stable

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BMC Ecology and Evolution

ISSN: 2730-7182

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