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Fig. 3 | BMC Evolutionary Biology

Fig. 3

From: The psoriasis-associated deletion of late cornified envelope genes LCE3B and LCE3C has been maintained under balancing selection since Human Denisovan divergence

Fig. 3

Population genetics summary statistics (a) Y-axis of the boxplot shows the nucleotide diversity (π) and (b) Tajima’s D in three different populations (CEU: Central Europeans from Utah; CHB: Han Chinese from Beijing; and YRI: Yoruba from Ibadan Nigeria). The red boxes represent all regions of the genome that are predicted to be evolving under neutrality, whereas the blue boxes represent the data points from the LCE3BC haplotype block. The green boxes represent π and Tajima’s D scores calculated for the size-matched downstream regions of non-exonic ancient deletions. These deletions are comparable to the LCE3BC deletion in the sense that they were also found to have evolved before Human Neanderthal/Denisovan divergence and that they are similarly high in allele frequency [58]. P-values (Wilcoxon Test) are shown on top of the comparisons

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