Fig. 1From: The protein subunit of telomerase displays patterns of dynamic evolution and conservation across different metazoan taxaEvolution of TERT across the Animal kingdom. Phylogenetic tree of TERT sequences from representative metazoan phyla, early-branching metazoans and unicellular relatives of metazoans constructed using the maximum-likelihood method. Bootstrap support percentages from 1000 replicates are labelled at the nodes. Scale bar denotes substitutions per site. Branches that contained less than 30% boostrap replicates were collapsed. Full list of species used and accession numbers can be obtained from Additional file 1: Table S2. Figure inset shows a schematic diagram of the canonical telomerase enzyme bound to the telomeric DNA substrate and the telomerase RNA template. The domain structure of TERT is also shown: the TEN domain with the GQ motif, the TRBD domain with the CP, QFP and T motifs, the RT domain with the 1, 2, A, B′, C, D and E motifs, the N-terminal linker and the CTE regionBack to article page