Parameter | Description | Range or value |
---|---|---|
α | Tumour emergence rate | 0.5, 0.75, 1. |
λ_{a, i} | Cancer initiation rate in the key organ |
If scenario 1 or 3, λ_{a, i} = 0.01 ∗ i If scenario 2, λ_{a} = 0 |
λ_{b, j} | Cancer initiation rate in the auxiliary organ |
If scenario 2 or 3, λ_{b, j} = 0.01 ∗ j If scenario 1, λ_{b} = 0 |
i and j | Cancer resistance strategy in the key and the auxiliary organ, respectively. | ℕ ∈ [1, 10] |
b _{ min} | The minimal and maximal fecundity rates | 0.1, 0.2, 0.3 |
b _{ max} | 0.5 | |
K | Carrying capacity | 10,000 |
d _{ H} | Mortality rate of healthy individuals | d_{H} ∼ Unif(10^{−2}, 5.10^{−2}) |
m | Mutation rate | m ∼ Unif(10^{−10}, 10^{−6}) |
τ_{12}, τ_{23} and τ_{33} | Probability to have a cancer of stage 2, 3 and 4 (metastasis) when you have a cancer of stage 1, 2 and 3, respectively. |
τ_{12} ∼ Unif(0.1, 0.9) τ_{23} ∼ Unif(0.1, 0.9) If Scenario 3, τ_{33} ∼ Unif(0.1,0.9) If Scenario 1 or 2, τ_{33} = 0 |
δ | The lethality of cancer in the key and the auxiliary organ | δ ∼ Unif(1/10, 1/2)for the key organ and δ ∼ Unif(2, 10) for the auxiliary organ |
c | Constant to manage the strength of cancer impact on organism’s mortality | c ∼ Unif(1, 19) |