Table 2 Sensitivity and specificity of filtering software over different error types
sensitivity | prokaryotic MSAs | eukaryotic MSAs | ||||
frameshifts | scrambled | insertions | frameshifts | scrambled | insertions | |
HmmCleaner | 96.95% | 96.24% | 99.24% | 95.99% | 96.26% | 99.34% |
PREQUAL | 93.13% | 96.77% | 99.83% | 85.64% | 97.34% | 99.95% |
BMGE | 16.00% | 19.23% | 97.55% | 8.57% | 12.57% | 96.16% |
OD-seq | 20.11% | 25.09% | 59.89% | 8.08% | 9.34% | 59.80% |
GUIDANCE2 | 4.90% | 5.37% | 0.25% | 2.33% | 3.25% | 1.69% |
specificity | prokaryotic MSAs | eukaryotic MSAs | ||||
frameshifts | scrambled | insertions | frameshifts | scrambled | insertions | |
HmmCleaner | 87.28% | 87.24% | 85.64% | 94.70% | 94.70% | 94.63% |
PREQUAL | 92.80% | 92.78% | 92.76% | 94.77% | 94.65% | 94.59% |
BMGE | 91.01% | 90.88% | 91.10% | 97.05% | 96.93% | 96.94% |
OD-seq | 94.48% | 94.46% | 92.55% | 95.20% | 95.25% | 94.90% |
GUIDANCE2 | 99.55% | 99.48% | 99.85% | 98.47% | 98.35% | 98.51% |